Venous Thromboembolism in Women Undergoing Assisted Reproductive Technologies: Data from the RIETE Registry

Elvira Grandone; Pier Paolo Di Micco; Michela Villani; Donatella Colaizzo; Carmen Fernández-Capitán; Jorge Del Toro; Vladimir Rosa; Alessandra Bura-Riviere; Isabelle Quere; Ángeles Blanco-Molina; Maurizio Margaglione; Manuel Monreal; for the RIETE Investigators

doi:10.1055/s-0038-1673402

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2018; 118(11): 1962-1968
DOI: 10.1055/s-0038-1673402

Stroke, Systemic or Venous Thromboembolism

Georg Thieme Verlag KG Stuttgart · New York

Venous Thromboembolism in Women Undergoing Assisted Reproductive Technologies: Data from the RIETE Registry

Elvira Grandone

¹Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy

,

Pier Paolo Di Micco

²Department of Internal Medicine, Ospedale Fatebenefratelli, Napoli, Italy

,

Michela Villani

¹Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy

,

Donatella Colaizzo

¹Thrombosis and Haemostasis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy

,

Carmen Fernández-Capitán

³Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain

,

Jorge Del Toro

⁴Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain

,

Vladimir Rosa

⁵Department of Internal Medicine, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain

,

Alessandra Bura-Riviere

⁶Department of Vascular Medicine, Hôpital de Rangueil, Toulouse, France

,

Isabelle Quere

⁷Department of Vascular Medicine, Hôpital Saint Eloi, Montpellier, France

,

Ángeles Blanco-Molina

⁸Department of Internal Medicine, Hospital Universitario Reina Sofía, Córdoba, Spain

,

Maurizio Margaglione

⁹Department of Medical Genetics, University of Foggia, Foggia, Italy

,

Manuel Monreal

¹⁰Department of Internal Medicine, Hospital Universitario Germans Trias i Pujol de Badalona, Universidad Católica de Murcia, Barcelona, Spain

,

for the RIETE Investigators

› Author Affiliations

Abstract

Venous thromboembolism (VTE) during or after assisted reproductive technologies (ART) is predicted to rise due to the increased number of women undergoing this technique. We present data collected in the RIETE registry up to October 2016. Overall, 41 (0.6%) out of 6,718 women of childbearing age with VTE had an ART-related event. Most of them underwent autologous ART cycles; 23 had isolated deep vein thrombosis (DVT) (56.1%), 12 isolated pulmonary embolism (PE) (29.3%) and 6 simultaneous occurrence of both the events (14.6%). VTE occurred in 20 successful and 21 unsuccessful (i.e. not resulting in a clinical pregnancy) ART cycles. No recurrence was observed at 90 days. Logistic regression showed that isolated PE was significantly more frequent than DVT alone or combined with PE in unsuccessful in vitro fertilization (IVF) (odds ratio [OR]: 4.13, 95% confidence interval [CI]: 1.4–12.4), as well as in contraceptive users (OR: 2.96, 95% CI: 1.95–4.5) and in puerperium (OR: 1.96, 95% CI: 1.16–3.3). After grouping isolated PE and DVT + PE, we found that PE was significantly more frequent in women with unsuccessful IVF and higher body mass index (OR: 5.0, 95% CI: 1.2–20.7 and OR: 1.0, 95%CI: 1.0–1.1, respectively). These data document a higher risk of PE in unsuccessful cycles than in successful ones. The risk is higher than that observed during pregnancy, puerperium and contraception.

Keywords

assisted reproductive technologies - venous thromboembolism - pregnancy

Full Text

References

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Supplementary Material

Supplementary Material Appendix A